The draw was held in the Swiss city of Nyon on Friday and saw 16 remaining clubs in Europe's second biggest club tournament paired with each other. Besiktas will go to Piraeus for the first leg of the two-leg clash on March 9. The return leg in Istanbul will be on March 16.
The nearest Besiktas came to lifting a major European honor was reaching the UEFA Cup's last eight in 2002-03 season and the European Cup quarter-finals in the 1986-87 season.
Here are the full draw results:
Celta Vigo (Spain) - Krasnodar (Russia)
APOEL Nicosia (Greek Cyprus) - Anderlecht (Belgium)
Schalke (Germany) - Borussia Monchengladbach (Germany)
Lyon (France) - Roma (Italy)
Rostov (Russia) - Manchester United (England)
Olympiacos (Greece) - Besiktas (Turkey)
Gent (Belgium) - Genk (Belgium)
FC Copenhagen (Denmark) - Ajax (Netherlands)