The Gaza-based Health Ministry said Sunday’s strikes targeted a residential block belonging to the Al-Barsh and Alwan families in the town of Jabalia.
Women and children were among the dead, with dozens still missing under rubble piles.
The first responders and locals were searching for the wounded and more bodies were believed to be under the rubble.
Many of those injured, including children, were taken to nearby medical centres, which are already overwhelmed with patients.
Medics in central Gaza’s Deir El-Balah said at least 12 Palestinians were killed and dozens wounded, while in Rafah in the south, an Israeli air attack on a house left at least four people dead.
About 19,000 Palestinians have been killed in Gaza since October 7.
Meanwhile, Israel has also ramped up its artillery shelling in southern Gaza, hitting the cities of Khan Younis and Rafah, where the majority of displaced Palestinians are sheltering.
The stepping up of bombardments in the south has worsened the humanitarian situation, with starving people scrambling for food and water, grabbing them from aid trucks in desperation.
The United Nations estimates that 1.9 million people – about 80 percent of Gaza’s population – have been displaced by the war.